| 1. | The mechanism has been termed cumulative feedback inhibition .
这种机制就叫作累加反馈抑制。 |
| 2. | Cumulative feedback inhibition
累积性反馈抑制 |
| 3. | Concerted feedback inhibition
协同反馈抑制 |
| 4. | 7 . build - in feedback inhibition circuit and volume control . 8 . red indicative light on the mic
13 .具有一组有线话筒输入接口，独立音量调节 |
| 5. | Asn5lys also shows a moderate release of the feedback inhibition with comparable specific enzymatic activity to the wild type arog
第二部分工作研究了aorg的n -末端的功能。 |
| 6. | These data implicate that the structural " d2 " symmetry is essential conformation for the signal transmission of feedback inhibition
“ dz ”对称性结构是aiog正常反馈抑制功能的必要结构形式。 |
| 7. | Feedback inhibition the inhibition of the activity of an enzyme ( often the first ) in a multienzyme reaction sequence by the product of that sequence
反馈抑制：在多酶反应体系中，反应的最终产物抑制最初反应酶的活性（通常是第一个酶） 。 |
| 8. | Double - mutations trp215ala / his217ala and leul6his / his217leu cause completely desensitization with no decrease in enzymatic activity . these results suggest that mutations at these residues cause the destruction of the symmetry , and interfere with the signal transmission of feedback regulation , which leads to the partially or completely relief of feedback inhibition
这些结果说明“ dz ”对称性相关氨基酸残基的点突变和双突变导致了对称性的变化，影响了反馈抑制信号的传递，因此能够部分或完全解除户曲g的反馈抑制。 |
| 9. | In escherichia coli , arog gene encodes phenylalanine - sensitive 3 - deoxy - d - arabino - heptulosonate - 7 - phosphate synthase isoenzyme arog that catalyzes the first committed step of shikimate pathway . here we study the essential amino acid residues involved in the formation of feedback inhibition site of arog , and the effects of n - terminus on feedback inhibition and its quaternary structure , and the importance of the structural " d2 " symmetry to allosteric inhibition
本博士论文工作以大肠杆菌k - 12来源的arog为研究对象，通过定点突变、反馈抑制实验和酶学动力学参数的测定，深入地研究了arog的反馈抑制位点的特性，并对arog的n -末端在反馈抑制机理和维持稳定四级结构中的作用，以及蛋白质结构的“ d2 ”对称性对酶功能的重要性等进行了具体的研究。 |
| 10. | The n - terminus truncated mutant can not form tight dimeric and tetrameric structure , and leads to the destruction of the quaternary structure , which is quite the contrary to wild type arog . these data indicate that n - terminus of arog is not only involved in the feedback inhibition , but also plays a role in the formation of stable dimer which is an essential structure for its enzymatic activity . according to the 3d structure , " d2 " symmetry of arog , to which contributed by leu 16 , trp215 and his217 , is essential for the feedback inhibition
对“ dz ”对称性相关的氨基酸leul6 、 trpz15和hisz17进行点突变和双突变研究结果表明: l )在1mm苯丙氨酸的存在下， leul6ala 、 trpz15ala和hisz17ala能解除35一70 %的反馈抑制， t印2巧ala的比活降低65 %以上，其余两者的比活与野生型相近; 2 )在lmm苯丙氨酸的存在下，导入双点突变trpz1sai洲isz17ala和leul6hi撇isz17leu后能够完全解除arog的反馈抑制，同时保持与野生型相当的比活。 |
